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1. Introduction by Dave DeMets
2. Neaton-DeMets DMC Video Lectures
2.1 Lecture 1: DMC Structure and Function (1:34:17) YouTube
Lecture describing the history, rationale, structure, and function of DMCs.
2.2 Lecture II: DMC Case Studies (1:43:39) YouTube
The speakers share examples of DMC activity from actual completed trials that illustrate the challenges of determining early interim evidence for benefit, potential harm or futility or other possible complications.
2.3 Lecture III: DMC Statistical Tools (1:17:45) YouTube
Presenters describe some statistical methods such as group sequential and conditional power and how they are used to monitor accumulating data for evidence of benefit, potential harm, or futility.
3. 2020 Seattle Symposium on Data Monitoring Committees
3.1 Lecture 1: Susan Ellenberg, PhD – DMC Structure and Function (1:59:20) YouTube
Seattle_Symposium_Susan_Ellenberg_Slides (PPT)
The history, rational, structure, and function of a DMC are described using examples to illustrate the key issues.
3.2 Lecture II: Janet Wittes, PhD – Independent Statistician and DMC Reports (2:32:52) YouTube
DMC reports must be prepared and presented to the DMC for their review. The lecturer provides recommendations for report preparation and structure to allow for effective and efficient DMC review.
3.3 Lecture III: Tom Fleming, PhD – DMC Best Practices (2:42:31) YouTube
Based on 5 decades of DMC experience, Dr. Fleming discusses the lessons that have been learned and captured into best DMC practices or principles.
4. Additional Lectures
DeMets_DMC_FDA_Statistical_Overview (PPT)
Lecture Dr. DeMets gave to the Food and Drug Administration on useful statistical methods for interim monitoring of accumulating data for early evidence of convincing benefit, potential harm, or trial futility.
4.2 Stuart Pocock, PhD – DMC Scenarios (0:41:17) YouTube
This lecture provides a brief overview of common statistical methods for interim analyses, with a primary focus on DMC scenarios that were challenging or instructive for the DMC.
4.3 Matt Downs, MPH – DMC Reports: A Graphical Approach (1:35:46) YouTube
DMC Reports: A Graphical Approach (PPT)
Using the graphic power of leading statistical software is an effective and efficient approach to DMC report generation, which has been proven to be well accepted by DMC members. This lecture provides insights and examples of such presentation.
5. DMC Clinician Experiences
DMC Commentaries
The following are commentaries by leading clinicians experienced in DMCS as a member or as DMC chair. They share what they have experienced that makes DMC participation a valuable and rewarding service.
5.1 Barry Davis, MD/PhD, University of Texas School of Public Health (0:22:27) YouTube
5.2 Chris Granger, MD, Duke University (0:36:17) YouTube
5.3 Charles Hennekens, MD/DPH, Florida Atlantic University (0:27:41) YouTube
5.4 Jean Rouleau, MD, Montreal Heart Institute (0:29:44) YouTube
5.5 Peter Sandercock, MD, University of Edinburgh (0:30:49) YouTube
5.6 Lew Smith, MD, Northwestern University (0:28:40) YouTube
5.7 Richard Whitley, MD, University of Alabama (0:13:40) YouTube
DMC Conversations with Dave DeMets
These six clinicians, very experienced in DMCs as a member or chair, engaged in a conversation with Dave DeMets on issues they had while serving on a DMC and wanted to share. In addition, Dr. Rockhold has extensive DMC experience from many years in industry and most recently at Duke University.
5.8 William Kelly, MD, Thomas Jefferson University (0:19:23) YouTube
5.9 Marc Pfeffer, MD, PhD, Harvard University (0:31:54) YouTube
5.10 Peter Sandercock, MD, University of Edinburgh (0:26:33) YouTube
5.11 Richard Whitley, MD, University of Alabama (0:27:17) YouTube