Additional Lectures

Lecture 4.1:  Dave DeMets, PhD - Statistical Methods for DMCs

Lecture IV: Dave DeMets (1:06:32) (PowerPoint Slides)

This is the FDA lecture on useful statistical methods for interim monitoring of accumulating data for early evidence of convincing benefit, potential harm or trial futility.
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Lecture 4.2:  Stuart Pocock, PhD - DMC Scenarios

Lecture V: Stuart Pocock (0:41:17)

This lecture gives a brief overview of common statistical methods for interim analyses but focuses mostly on DMC scenarios that were challenging or instructive for the DMC.

Lecture 4.3:  Matt Downs, MPH - DMC Reports: A Graphical Approach

Lecture VI: Matt Downs (1:35:46) (PowerPoint Slides)

An effective and efficient approach to DMC Report presentation is to use the graphic power of leading statistical software, which has proven to be well accepted by DMC members. This lecture provides insights and examples of such presentation.